A DATA INTEGRATION APPROACH TO MAPPING OCT4 GENE REGULATORY NETWORKS OPERATIVE IN EMBRYONIC STEM CELLS AND EMBRYONAL CARCINOMA CELLS.

A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells.

It is essential to understand the network of transcription factors TV Package controlling self-renewal of human embryonic stem cells (ESCs) and human embryonal carcinoma cells (ECs) if we are to exploit these cells in regenerative medicine regimes.Correlating gene expression levels after RNAi-based ablation of OCT4 function with its downstream targ

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A Note on Weak vs. Strong Generation in Human Language

This paper argues that various important results of formal language theory (e.g., the so-called Chomsky Hierarchy) may in fact be illusory as far as the human language faculty is concerned, as has been repeatedly emphasized by Chomsky himself.The paper takes up nested dependencies and cross-serial dependencies, the two important dependencies that t

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Unilateral leukemic infiltration and acute angle closure as the first sign of B-cell acute lymphoblastic leukemia relapse

Objective: Unilateral ocular leukemic infiltration with acute angle closure is an infrequent complication of B-cell acute lymphoblastic leukemia (ALL-B).We present a clinical case of leukemic ocular infiltration as the sole manifestation of ALL-B relapse.Methods: Case descriptionResults: A 15-year-old female with a history of acute lymphoblastic ke

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Symptom frequency and development of a generic functional disorder symptom scale suitable for use in studies of patients with irritable bowel syndrome, fibromyalgia syndrome or chronic fatigue syndrome

Objectives: To describe the extent to which irritable bowel syndrome (IBS), fibromyalgia syndrome (FMS), and chronic fatigue syndrome (CFS) exhibit symptom overlap, and to validate a patient-derived, generic symptom questionnaire.Methods: A patient-derived 61-item symptom-frequency questionnaire was completed by participants recruited through IBS,

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